Settings are used to configure the pathway prediction, and include a list of package/s and a truncation strategy:

• Packages: all available rules within the selected packages are used for pathway prediction.
• Truncation strategy limits the combinatorial explosion in pathway prediction. A truncation strategy can include:
  1. A relative reasoning model and a probability threshold.
  2. Basic truncators like e.g. RuleLikelihood, or Maximum Number of Nodes.

The available settings are listed here: https://envipath.org/setting